Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL312035 | 0.96 | BBOX1 (0.46) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylamide SCHEMBL8526918 | 0.94 | BBOX1 (0.47) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylamide SCHEMBL1129323 | 0.94 | BBOX1 (0.47) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylic Acid SCHEMBL577496 | 0.90 | BBOX1 (0.50) | BBOX1KMT2AATMACHEBCHE | |
| Acrylic Acid SCHEMBL5284669 | 0.88 | BBOX1 (0.52) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylamide SCHEMBL5721895 | 0.84 | ALDH1A1 (0.42) | BBOX1KMT2AATMALDH1A1TSHR | |
| Acrylamide SCHEMBL2111288 | 0.83 | ALDH1A1 (0.46) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylic Acid SCHEMBL578283 | 0.83 | BBOX1 (0.55) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylic Acid SCHEMBL11323113 | 0.83 | BBOX1 (0.55) | BBOX1KMT2AATMALDH1A1ACHE | |
| Acrylic Acid SCHEMBL4148615 | 0.81 | BBOX1 (0.53) | BBOX1KMT2AATMALDH1A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465080-B2 | FOR OVERHEAD PROJECTORS | ARKWRIGHT INCORPORATED | 2002-10-15 | — | — | US | disclosed |
| US-20020142137-A1 | Electrophotographic media for use in high speed color copiers and printers | ARKWRIGHT ADVANCED COATING, INC. | 2002-10-03 | — | — | US | disclosed |
| WO-2002058929-A1 | ELECTROPHOTOGRAPHIC MEDIA FOR USE IN HIGH SPEED COLOR COPIERS AND PRINTERS | ARKWRIGHT INCORPORATED (US) | 2002-08-01 | — | — | WO | disclosed |
| EP-0474278-B1 | Dry toner imaging films possessing an anti-static matrix layer | ARKWRIGHT INC (US) | 1997-11-12 | — | — | EP | disclosed |
| US-5104731-A | DRY TONER IMAGING FILMS POSSESSING AN ANTI-STATIC MATRIX LAYER | ARKWRIGHT INCORPORATED (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0474278-A1 | Dry toner imaging films possessing an anti-static matrix layer | ARKWRIGHT INC. (US) | 1992-03-11 | — | — | EP | disclosed |