Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501150 | 0.92 | CA1 (0.47) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7503499 | 0.92 | CA1 (0.51) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7504416 | 0.91 | PTGS2 (0.49) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL7504983 | 0.89 | RXRA (0.53) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7505619 | 0.88 | PTGS2 (0.45) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7500284 | 0.88 | CA1 (0.43) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7503904 | 0.87 | RXRA (0.53) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7500801 | 0.87 | RXRA (0.53) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7506149 | 0.86 | CA2 (0.47) | CA1CA2CA12CA9CA14 | |
| SCHEMBL7499302 | 0.86 | CA1 (0.51) | CA1CA2CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6090834-A | ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS | G.D. SEARLE & CO. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |