⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880297 | 0.82 | — | — | |
| SCHEMBL94284 | 0.78 | — | — | |
| SCHEMBL263431 | 0.70 | — | — | |
| SCHEMBL5827 | 0.67 | — | — | |
| SCHEMBL5596889 | 0.67 | — | — | |
| SCHEMBL2155072 | 0.67 | — | — | |
| SCHEMBL17158347 | 0.64 | ALDH1A1 (0.33) | — | |
| SCHEMBL8171029 | 0.64 | ALDH1A1 (0.33) | — | |
| SCHEMBL9290864 | 0.64 | — | — | |
| SCHEMBL12478173 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2022226-A | — | — | None | — | — | JP | disclosed |
| EP-1439174-B1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS AS p38 MAP KINASE INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7235551-B2 | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-26 | — | — | US | disclosed |
| EP-0509354-B1 | Amino acid derivatives | HOFFMANN LA ROCHE (CH) | 2000-08-23 | — | — | EP | disclosed |
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5260446-A | Azo dye precursors | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |
| EP-0509354-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-21 | — | — | EP | disclosed |
| EP-0433879-A2 | Aminothiazoles | BASF Aktiengesellschaft (DE) | 1991-06-26 | — | — | EP | disclosed |
| JP-H0222226-A | REMEDY FOR OSTEOPATHIC DISEASE CONTAINING PGD ANALOG COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUT CO LTD | 1990-01-25 | — | — | JP | disclosed |
| US-4474777-A | ATHEROSCLEROSIS | HOFFMANN-LA ROCHE INC. (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0084357-A1 | Benzodiazepines, their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-07-27 | — | — | EP | disclosed |
| US-3998827-A | HYPOTENSIVE AGENTS | THE UPJOHN COMPANY (US) | 1976-12-21 | — | — | US | disclosed |