⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750672 | 0.78 | — | — | |
| SCHEMBL263431 | 0.73 | — | — | |
| SCHEMBL4035473 | 0.72 | — | — | |
| SCHEMBL5827 | 0.70 | — | — | |
| SCHEMBL2155072 | 0.70 | — | — | |
| SCHEMBL28060645 | 0.67 | TSHR (0.31) | — | |
| SCHEMBL12478173 | 0.67 | — | — | |
| SCHEMBL9290864 | 0.67 | — | — | |
| SCHEMBL17158347 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL8171029 | 0.67 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | claimed |
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2015-11-19 | — | — | US | claimed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | claimed |
| EP-1963313-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | MADRIGAL PHARMACEUTICALS INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1628968-B1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-04-06 | — | — | EP | claimed |
| US-20100190979-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. | 2010-07-29 | — | — | US | claimed |
| US-20100168419-A1 | Diacylglycerol Acyltransferase Inhibitors | BOLIN DAVID ROBERT | 2010-07-01 | — | — | US | claimed |
| US-7714126-B2 | Diacylglycerol acyltransferase inhibitors | VIA PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | claimed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | claimed |
| EP-1820503-A2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | Pfizer Italia S.r.l. (IT) | 2007-08-22 | — | — | EP | claimed |
| WO-1998042819-A1 | DETERGENT COMPOSITION FOR USE WITH A CLEANING IMPLEMENT COMPRISING A SUPERABSORBENT MATERIAL AND KITS COMPRISING BOTH | THE PROCTER & GAMBLE COMPANY (US) | 1998-10-01 | — | — | WO | claimed |
| EP-0623166-B1 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC AND CATIONIC DETERGENT SURFACTANTS AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL | PROCTER & GAMBLE (US) | 1996-06-05 | — | — | EP | claimed |
| US-5454983-A | Liquid hard surface detergent compositions containing zwitterionic and cationic detergent surfactants and monoethanolamine and/or beta-aminoalkanol | THE PROCTER & GAMBLE COMPANY (US) | 1995-10-03 | — | — | US | claimed |
| EP-0623166-A1 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC AND CATIONIC DETERGENT SURFACTANTS AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL. | PROCTER & GAMBLE (US) | 1994-11-09 | — | — | EP | claimed |
| US-5336445-A | Aqueous mixtures with polar solvents for removal of grease and heavy soils from glass without streaking | THE PROCTER & GAMBLE COMPANY (US) | 1994-08-09 | — | — | US | claimed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | claimed |
| EP-0513240-A4 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC DETERGENT SURFACTANT AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL | — | 1993-10-20 | — | — | EP | claimed |
| WO-1993015173-A1 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC AND CATIONIC DETERGENT SURFACTANTS AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL | THE PROCTER & GAMBLE COMPANY (US) | 1993-08-05 | — | — | WO | claimed |
| EP-0513240-A1 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC DETERGENT SURFACTANT AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL | THE PROCTER & GAMBLE COMPANY (US) | 1992-11-19 | — | — | EP | claimed |
| WO-1991011505-A1 | LIQUID HARD SURFACE DETERGENT COMPOSITIONS CONTAINING ZWITTERIONIC DETERGENT SURFACTANT AND MONOETHANOLAMINE AND/OR BETA-AMINOALKANOL | THE PROCTER & GAMBLE COMPANY (US) | 1991-08-08 | — | — | WO | claimed |