Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162886 | 0.89 | EDNRA (0.49) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6159406 | 0.88 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7507367 | 0.88 | EDNRA (0.48) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7506638 | 0.86 | EDNRA (0.45) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7503953 | 0.81 | EDNRA (0.53) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434286 | 0.80 | EDNRA (0.64) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6579951 | 0.79 | SMN1; SMN2 (0.41) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3834407 | 0.79 | EDNRA (0.64) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7506376 | 0.79 | EDNRA (0.51) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6160979 | 0.79 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863896-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | claimed |