SCHEMBL7507461

SCHEMBL7507461

CC(=O)OC(C(=O)Nc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
CYP3A4 P08684 1/20 0.43
NPSR1 Q6W5P4 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
ALOX12 P18054 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TSHR P16473 1/20 0.39
CASP3 P42574 1/20 0.38
CASP2 P42575 1/20 0.38
CASP7 P55210 1/20 0.38
CASP6 P55212 1/20 0.38
CASP8 Q14790 1/20 0.38
TUBB4A P04350 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7505403 0.89 KDM4E (0.41) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7505400 0.89 KDM4E (0.41) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7513274 0.85 KMT2A (0.41) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7508742 0.84 NPSR1 (0.40) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7507607 0.84 RAB9A (0.45) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7503533 0.83 MEN1 (0.42) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7503527 0.83 MEN1 (0.42) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7512424 0.83 MEN1 (0.42) ALDH1A1NPSR1KDM4EMEN1NPC1
SCHEMBL7508042 0.83 ALDH1A1 (0.50) ALDH1A1NPSR1MEN1MAPTKMT2A
SCHEMBL7503003 0.83 KDM4E (0.54) ALDH1A1NPSR1KDM4EMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001934-B1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER (US) 2002-11-27 EP disclosed
US-6300363-B1 USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS PFIZER INC. 2001-10-09 US disclosed
EP-1001934-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 2000-05-24 EP disclosed
WO-1999005104-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1999-02-04 WO disclosed