Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508742 | 0.90 | NPSR1 (0.40) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7507607 | 0.87 | RAB9A (0.45) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7512424 | 0.86 | MEN1 (0.42) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7503533 | 0.86 | MEN1 (0.42) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7503527 | 0.86 | MEN1 (0.42) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7508042 | 0.86 | ALDH1A1 (0.50) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL6953063 | 0.86 | MEN1 (0.46) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7508275 | 0.85 | MEN1 (0.43) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7507461 | 0.85 | ALDH1A1 (0.43) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7502892 | 0.84 | SERPINE1 (0.48) | KMT2AMEN1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |