SCHEMBL7507481

SCHEMBL7507481

CC(=O)NCn1c(Cl)c(Cl)c(C#N)c1-c1ccc(Cl)c(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 9/20 0.37
NOTUM Q6P988 2/20 0.37
MEN1 O00255 2/20 0.35
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.35
KMT2A Q03164 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HTT P42858 1/20 0.35
ATM Q13315 1/20 0.35
GPR35 Q9HC97 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CCR2 P41597 1/20 0.34
MAP3K14 Q99558 1/20 0.34
PRKCZ Q05513 1/20 0.34
MET P08581 1/20 0.34
KDR P35968 1/20 0.34
KDM4E B2RXH2 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7509402 0.91 NOTUM (0.39) ABL1NOTUMMEN1LMNAMAPT
SCHEMBL7505132 0.84 NPC1 (0.39) MEN1KMT2ASMN1; SMN2CCR2MET
SCHEMBL9336008 0.80 AHR (0.36) LMNAMAPTCCR2KDM4EHPGD
SCHEMBL9216319 0.79 MAP3K14 (0.39) NOTUMMEN1LMNAMAPTKMT2A
SCHEMBL7500290 0.79 AHR (0.37) NOTUMMEN1LMNAMAPTKMT2A
SCHEMBL9055776 0.78 P2RX3 (0.37) ABL1MEN1KMT2ACCR2MET
SCHEMBL10590897 0.78 MEN1 (0.35) MEN1LMNAMAPTKMT2ACCR2
SCHEMBL9056032 0.77 AHR (0.36) ABL1MEN1LMNAMAPTKMT2A
SCHEMBL10590186 0.77 TDP1 (0.46) MEN1MAPTKMT2AHTTL3MBTL1
SCHEMBL9228443 0.75 DCUN1D1 (0.37) MEN1LMNAKMT2AL3MBTL1CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5130328-A Lima bean leaves AMERICAN CYANAMID COMPANY (US) 1992-07-14 US claimed
JP-5208955-A None JP disclosed
EP-0530515-B1 Process for the preparation of N-halomethylpyrrole and intermediates BASF AG (DE) 2002-11-06 EP disclosed
JP-H05208955-A N-ALKANOYLAMINOMETHYL AND N-AROYLAMINOMETHYL PYRROLE INSECTICIDAL AND ACARICIDAL AGENTS AMERICAN CYANAMID CO 1993-08-20 JP disclosed
EP-0530515-A1 N-Alkanoylaminomethyl and N-Aroylaminomethyl pyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1993-03-10 EP disclosed
US-5130328-A Lima bean leaves AMERICAN CYANAMID COMPANY (US) 1992-07-14 US disclosed