Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.54 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | HTR7 | P34969 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509044 | 0.85 | DRD2 (0.49) | DRD2DRD4DRD3HTR7MAPK1 | |
| SCHEMBL7498865 | 0.85 | ACHE (0.51) | DRD2DRD4DRD3ACHEHTR1A | |
| SCHEMBL7507348 | 0.81 | DRD4 (0.72) | DRD2DRD4DRD3HTR7HTR1A | |
| Hydrochloric Acid SCHEMBL7989155 | 0.80 | DRD4 (0.71) | DRD2DRD4DRD3HTR7HTR1A | |
| SCHEMBL8646219 | 0.79 | MAPK1 (0.72) | DRD2DRD4DRD3HTR7MAPK1 | |
| SCHEMBL7424054 | 0.74 | DRD4 (0.69) | DRD2DRD4DRD3HTR7MAPK1 | |
| SCHEMBL27603307 | 0.72 | ACHE (0.60) | DRD2ACHEHTR1A | |
| SCHEMBL7500479 | 0.71 | DPP8 (0.49) | DRD2DRD4DRD3ACHEHTR1A | |
| SCHEMBL9228414 | 0.70 | DRD4 (0.62) | DRD2DRD4DRD3HTR7MAPK1 | |
| SCHEMBL6195902 | 0.69 | HTR3E (0.64) | DRD2DRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |
| EP-0931067-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011068-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1998-03-19 | — | — | WO | disclosed |