Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494608 | 0.88 | CYP3A4 (0.52) | CYP3A4TDP1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7103526 | 0.86 | ERN1 (0.45) | CYP3A4MAPTLMNAMEN1KMT2A | |
| Allisan SCHEMBL9328474 | 0.75 | ALDH1A1 (0.57) | CYP3A4LMNAKMT2ATDP1ALDH1A1 | |
| SCHEMBL31413031 | 0.75 | GPR35 (0.47) | CYP3A4TDP1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7902277 | 0.75 | GPR35 (0.47) | CYP3A4TDP1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1487913 | 0.73 | CA1 (0.53) | CYP3A4MAPTLMNAMEN1KMT2A | |
| SCHEMBL18830361 | 0.73 | GPR35 (0.46) | CYP3A4MAPTLMNAMEN1KMT2A | |
| SCHEMBL5110264 | 0.73 | AKR1C4 (0.56) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL11210616 | 0.73 | ERN1 (0.65) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL9423000 | 0.73 | DTYMK (0.44) | CYP3A4ALDH1A1CYP1A2CYP2C19GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259491-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | Abbott Laboratories (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001060802-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES, AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-08-23 | — | — | WO | disclosed |