Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 8/20 | 0.47 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508124 | 0.89 | PIM1 (0.49) | KDRALOX5ELANETDO2PLCG1 | |
| SCHEMBL7509779 | 0.89 | DYRK1A (0.50) | KDRALOX5IMPDH2ELANETDO2 | |
| SCHEMBL7507592 | 0.86 | ALOX5 (0.64) | KDRALOX5IMPDH2ELANEMAPK1 | |
| SCHEMBL7502639 | 0.86 | KDR (0.70) | KDRIMPDH2MAPK1HSD17B10PDGFRB | |
| SCHEMBL6586643 | 0.85 | ASH1L (0.59) | ALOX5IMPDH2ELANEMAPK1HSD17B10 | |
| SCHEMBL30695578 | 0.85 | ASH1L (0.59) | ALOX5IMPDH2ELANEMAPK1HSD17B10 | |
| SCHEMBL25034154 | 0.85 | KDR (0.73) | KDRALOX5IMPDH2MAPK1HSD17B10 | |
| SCHEMBL7515888 | 0.83 | KDR (0.41) | KDRPLCG1PIM1PIM3PIM2 | |
| SCHEMBL7508798 | 0.82 | JAK2 (0.52) | KDRALOX5IMPDH2ELANETDO2 | |
| SCHEMBL7508704 | 0.82 | IMPDH2 (0.55) | KDRALOX5IMPDH2ELANETDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |