Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 6/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30695578 | 1.00 | ASH1L (0.59) | ASH1LALOX5ELANEIMPDH2NR4A2 | |
| SCHEMBL7510320 | 0.85 | KDR (0.61) | ASH1LALOX5ELANEIMPDH2MAPK1 | |
| SCHEMBL31517697 | 0.80 | ALOX5 (0.71) | ASH1LALOX5ELANEIMPDH2NR4A2 | |
| SCHEMBL11515884 | 0.80 | ALOX5 (0.71) | ASH1LALOX5ELANEIMPDH2NR4A2 | |
| SCHEMBL28887322 | 0.80 | EGFR (0.44) | ASH1LALOX5ELANETDO2NR3C1 | |
| SCHEMBL25043136 | 0.79 | ASH1L (0.59) | ASH1LIMPDH2NR4A2MAPK1HSD17B10 | |
| SCHEMBL29824426 | 0.79 | ASH1L (0.63) | ASH1LIMPDH2NR4A2MAPK1HSD17B10 | |
| SCHEMBL23649189 | 0.79 | ASH1L (0.63) | ASH1LIMPDH2NR4A2MAPK1HSD17B10 | |
| SCHEMBL6321811 | 0.79 | CSNK2B (0.62) | ASH1L | |
| 3-Phenylindole SCHEMBL84056 | 0.79 | IMPDH2 (0.71) | ASH1LELANEIMPDH2NR4A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420015-A1 | Imidazolyl derivatives | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2004-05-19 | — | — | EP | disclosed |
| EP-1097150-B1 | IMIDAZOLYL DERIVATIVES | CONSEILS DE RECH SET D APPLIC (FR) | 2004-03-24 | — | — | EP | disclosed |
| US-20040002531-A1 | Imidazolyl derivatives | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTEFIQUES, S.A.S., A FRANCE CORPORATION | 2004-01-01 | — | — | US | disclosed |
| US-6509336-B1 | Prenyl transeferase inhibitors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2003-01-21 | — | — | US | disclosed |
| US-20030004342-A1 | Imidazolyl derivatives | BIOMEASURE, INC., A MASSACHUSETTS CORPORATION | 2003-01-02 | — | — | US | disclosed |
| US-6420555-B1 | IMIDAZOLE DERIVATIVES PRENYL TRANSFERASE INHIBITORS. | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2002-07-16 | — | — | US | disclosed |
| EP-1097150-A1 | IMIDAZOLYL DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2001-05-09 | — | — | EP | disclosed |
| EP-1094810-A1 | USE OF PRENYLTRANSFERASE INHIBITORS FOR PREPARING A MEDICINE FOR TREATING PATHOLOGIES RESULTING FROM HETEROTRIMERIC G PROTEIN MEMBRANE FIXATION | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002558-A1 | USE OF PRENYLTRANSFERASE INHIBITORS FOR PREPARING A MEDICINE FOR TREATING PATHOLOGIES RESULTING FROM HETEROTRIMERIC G PROTEIN MEMBRANE FIXATION | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2000-01-20 | — | — | WO | disclosed |
| WO-1999065898-A1 | IMIDAZOLYL DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES SAS (FR) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004342-A1 | Imidazolyl derivatives | TPI1, BCHE, CYP51A1 | ASH1L 3933/4885ALOX5 2023/4885ELANE 1051/4885 |
| US-20040002531-A1 | Imidazolyl derivatives | TPI1, BCHE, CYP51A1 | ASH1L 3933/4885ALOX5 2023/4885ELANE 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.