Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509159 | 0.87 | TBXA2R (0.41) | MAOAMAOBSLC6A2HTR2AHTR2C | |
| SCHEMBL8797519 | 0.81 | EDNRB (0.40) | SLC6A2HTR2AHTR2CSLC6A4MAPK1 | |
| SCHEMBL4465669 | 0.81 | MAOA (0.59) | MAOAMAOBHTR2AHTR2CCAMK2A | |
| SCHEMBL9527650 | 0.81 | NR3C2 (0.49) | MAOAMAOBADRA2A | |
| SCHEMBL9047807 | 0.79 | HTR2A (0.38) | MAOAMAOBSLC6A2HTR2AHTR2C | |
| SCHEMBL21996315 | 0.75 | MAOB (0.40) | MAOAMAOBSLC6A2HTR2AHTR2C | |
| SCHEMBL9063943 | 0.74 | TBXA2R (0.41) | SLC6A2HTR2AHTR2CSLC6A4AHR | |
| SCHEMBL7247480 | 0.74 | DYRK1A (0.40) | SLC6A2HTR2AHTR2CSLC6A4CAMK2A | |
| SCHEMBL11281780 | 0.73 | MAOB (0.46) | MAOAMAOBSLC6A2HTR2AHTR2C | |
| SCHEMBL4409906 | 0.73 | MAPK1 (0.44) | MAOAMAOBSLC6A2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974583-B1 | PHENYLPIPERIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-05-29 | — | — | EP | disclosed |
| US-6150355-A | ANALGESICS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-11-21 | — | — | US | disclosed |
| EP-0974583-A1 | PHENYLPIPERIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-01-26 | — | — | EP | disclosed |