Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115638 | 0.91 | MAOA (0.58) | METAP1KDM4EHTTCYP19A1CYP11B2 | |
| SCHEMBL1495967 | 0.88 | MAOA (0.58) | METAP1KDM4EHTTMAOAMAOB | |
| SCHEMBL29756894 | 0.88 | MAOA (0.58) | METAP1KDM4EHTTMAOAMAOB | |
| Sulfuric Acid SCHEMBL28143763 | 0.85 | MAOA (0.54) | KDM4EHTTMAOAMAOBHSD17B1 | |
| SCHEMBL27323916 | 0.83 | MAOA (0.51) | METAP1KDM4EHTTMIFMAOA | |
| SCHEMBL12457871 | 0.83 | CYP19A1 (0.48) | METAP1MIFMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL12272153 | 0.83 | CYP19A1 (0.48) | METAP1MIFMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29726357 | 0.81 | MAOB (0.58) | METAP1KDM4EHTTMAPTCYP19A1 | |
| SCHEMBL120284 | 0.81 | MAOB (0.58) | METAP1KDM4EHTTMAPTCYP19A1 | |
| SCHEMBL1512717 | 0.80 | METAP1 (0.69) | METAP1KDM4EHTTMIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |
| EP-1042320-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | AstraZeneca UK Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999026944-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENEKA UK LIMITED (GB) | 1999-06-03 | — | — | WO | disclosed |