Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.58 |
| ▸ | MAOA | P21397 | 5/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29726357 | 1.00 | MAOB (0.58) | MAOBMAOAMETAP1ACHEKDM4E | |
| SCHEMBL5146484 | 0.96 | MAOB (0.58) | MAOBMAOAMETAP1ACHEKDM4E | |
| SCHEMBL29392039 | 0.89 | MAOB (0.54) | MAOBMETAP1ACHEKDM4EHTT | |
| SCHEMBL251842 | 0.89 | MAOB (0.54) | MAOBMETAP1ACHEKDM4EHTT | |
| SCHEMBL14005914 | 0.88 | MAOA (0.55) | MAOBMAOAMETAP1ACHEKDM4E | |
| SCHEMBL115638 | 0.86 | MAOA (0.58) | MAOBMAOAMETAP1KDM4EHTT | |
| SCHEMBL27844074 | 0.83 | GSTP1 (0.46) | MAOBMAOAKDM4EHTTCYP2A6 | |
| SCHEMBL27861252 | 0.83 | GSTP1 (0.46) | MAOBMAOAKDM4EHTTCYP2A6 | |
| SCHEMBL27784239 | 0.83 | MAOA (0.56) | MAOBMAOA | |
| Butane SCHEMBL4688097 | 0.83 | BRD4 (0.52) | MAOBMETAP1ACHEKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119930666-A | Doped red organic room-temperature phosphorescent material based on red phosphorescent emitter and preparation method thereof | 江西科技师范大学 | 2025-05-06 | — | — | CN | claimed |
| CN-119881170-A | Agomei Latin intermediate method for detecting related substances in (a) | 江苏威奇达药业有限公司 | 2025-04-25 | — | — | CN | claimed |
| US-20250075147-A1 | FRAGRANCE AND FLAVOR COMPOSITIONS COMPRISING NEW FLAVOR AND FRAGRANCE INGREDIENTS | OSMO LABS, PBC | 2025-03-06 | — | — | US | claimed |
| CN-114591727-B | Organic long-afterglow luminescent material, preparation and application | 中国科学院上海有机化学研究所 | 2024-06-28 | — | — | CN | claimed |
| CN-115108928-B | Nitrogen mustard-tetralone derivative, preparation method and application thereof | 广东海洋大学 | 2024-06-11 | — | — | CN | claimed |
| CN-117567321-A | Preparation method of 7-methoxy naphthalene acetonitrile | 湖南省湘中制药有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-115925530-A | 3,4-dihydronaphthalene-1 (2H) -ketone compound, preparation method and application | 滨州医学院 | 2023-04-07 | — | — | CN | claimed |
| CN-115043742-A | Preparation method of dezocine | 南京大美生物制药有限公司 | 2022-09-13 | — | — | CN | claimed |
| CN-114591727-A | Organic long-afterglow luminescent material, preparation and application | 中国科学院上海有机化学研究所 | 2022-06-07 | — | — | CN | claimed |
| EP-2921473-B1 | 1-CYAN-1-(7-METHOXYL-1-NAPHTYL) METHANOL ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF | JIANGXI SYNERGY PHARMACEUTICAL CO LTD (CN) | 2017-09-27 | — | — | EP | claimed |
| US-20050182267-A1 | Reacting 7-methoxy-1-tetralone with cyanoacetic acid to form intermediate, in presence of catalytic benzylammonium heptanoate, removing water formed, forming 7-methoxy-3,4-dihydro-1-naphthalenyl)acetonitrile, hydrogenating with allyl compound in presence of Pd catalyst; intermediate for agomelatine | LES LABORATOIRES SERVIER (FR) | 2005-08-18 | — | — | US | claimed |
| US-20050182268-A1 | Process for the synthesis of (7-methoxy-3, 4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2005-08-18 | — | — | US | claimed |
| US-20050182276-A1 | Process for the synthesis and crystalline form of agomelatine | LES LABORATOIRES SERVIER (FR) | 2005-08-18 | — | — | US | claimed |
| EP-1564202-A1 | Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these | LES LABORATOIRES SERVIER (FR) | 2005-08-17 | — | — | EP | claimed |
| EP-1564203-A1 | New process for synthesizing (7-methoxy-1-naphtyl)acetonitrile and its application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2005-08-17 | — | — | EP | claimed |
| EP-1564204-A1 | New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2005-08-17 | — | — | EP | claimed |
| WO-2005026105-A2 | PROCESS FOR THE SYNTHESIS OF 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXYNAPHTHONITRILE | WYETH (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050054870-A1 | Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile | WYETH (US) | 2005-03-10 | — | — | US | claimed |
| EP-1107785-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012121-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182268-A1 | Process for the synthesis of (7-methoxy-3, 4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine | COMT, PNMT, DHPS | MAOB 92/4885MAOA 75/4885METAP1 888/4885 |
| US-20050182267-A1 | Reacting 7-methoxy-1-tetralone with cyanoacetic acid to form intermediate, in presence of catalytic benzylammonium heptanoate, removing water formed, forming 7-methoxy-3,4-dihydro-1-naphthalenyl)acetonitrile, hydrogenating with allyl compound in presence of Pd catalyst; intermediate for agomelatine | HAAO, MC3R, TH | MAOB 236/4885MAOA 73/4885METAP1 602/4885 |
| US-20050054870-A1 | Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile | HRH4, HRH1, HRH3 | MAOB 1173/4885MAOA 1793/4885METAP1 2646/4885 |
| US-20050182276-A1 | Process for the synthesis and crystalline form of agomelatine | MTNR1A, MCHR1, MTNR1B | MAOB 23/4885MAOA 10/4885METAP1 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.