Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510848 | 0.74 | TDP1 (0.37) | TDP1ALDH1A1CASP1CYP3A4MAPT | |
| SCHEMBL19240330 | 0.73 | ALDH1A1 (0.42) | TDP1ALDH1A1CASP1CYP3A4PARP1 | |
| SCHEMBL19175110 | 0.73 | ALDH1A1 (0.42) | TDP1ALDH1A1CASP1CYP3A4PARP1 | |
| SCHEMBL989990 | 0.73 | TSHR (0.40) | TDP1ALDH1A1MAPT | |
| SCHEMBL7721185 | 0.70 | — | — | |
| SCHEMBL11699485 | 0.70 | ALDH1A1 (0.46) | TDP1ALDH1A1CASP1CYP3A4PARP1 | |
| SCHEMBL4840129 | 0.70 | IDO1 (0.53) | CYP3A4MAPT | |
| SCHEMBL2865322 | 0.68 | ALDH1A1 (0.37) | TDP1ALDH1A1CASP1CYP3A4PARP1 | |
| SCHEMBL14661925 | 0.67 | ALDH1A1 (0.43) | TDP1ALDH1A1CASP1CYP3A4PARP1 | |
| SCHEMBL7451632 | 0.67 | GRM5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242427-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046200-A1 | NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |