Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097683 | 0.80 | ADRA1A (0.40) | ADRA1AADRA2ACA1CA2ACHE | |
| SCHEMBL7102182 | 0.74 | ADRA1A (0.36) | ADRA1AADRA2ACA1CA2ACHE | |
| SCHEMBL7100855 | 0.72 | KDM2B (0.35) | ADRA1AADRA2ACA1CA2ACHE | |
| SCHEMBL7098514 | 0.71 | SCN9A (0.36) | ADRA1A | |
| SCHEMBL7101986 | 0.70 | HTR1A (0.33) | ADRA1ACA1CA2 | |
| SCHEMBL7104921 | 0.70 | ADRA1A (0.36) | ADRA1AADRA2ACA1CA2CYP11B2 | |
| SCHEMBL7098163 | 0.68 | ADRA2A (0.65) | ADRA1AADRA2A | |
| SCHEMBL7098178 | 0.67 | DDB1 (0.35) | ADRA1A | |
| SCHEMBL8857004 | 0.67 | ADRA1A (0.43) | ADRA1ACA1CA2ACHECYP11B2 | |
| SCHEMBL8865462 | 0.67 | PARP1 (0.43) | ADRA1AADRA2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259491-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | Abbott Laboratories (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001060802-A1 | 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES, AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-08-23 | — | — | WO | disclosed |