Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.49 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427969 | 0.82 | ALDH1A1 (0.70) | GRM5HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL27761583 | 0.82 | ALDH1A1 (0.55) | GRM5HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL3427705 | 0.79 | ALDH1A1 (0.74) | GRM5HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL7416002 | 0.79 | HDAC1 (0.54) | GRM5HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL7348189 | 0.79 | NPSR1 (0.58) | HTTHDAC6CNR1CHRM1NAMPT | |
| SCHEMBL1116630 | 0.79 | ALDH1A1 (0.78) | GRM5HTTALDH1A1L3MBTL1MAPT | |
| SCHEMBL7348185 | 0.79 | NPSR1 (0.58) | HTTHDAC6CNR1CHRM1NAMPT | |
| SCHEMBL13495007 | 0.79 | NPSR1 (0.58) | HTTHDAC6CNR1CHRM1NAMPT | |
| SCHEMBL8740547 | 0.79 | NPSR1 (0.58) | HTTHDAC6CNR1CHRM1NAMPT | |
| SCHEMBL7348191 | 0.79 | NPSR1 (0.58) | HTTHDAC6CNR1CHRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575455-A2 | METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY | The Regents of the University of California (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153377-A2 | METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-08 | — | — | WO | disclosed |