Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761583 | 0.80 | ALDH1A1 (0.55) | HDAC1HDAC6ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7511254 | 0.79 | GRM5 (0.54) | HDAC1HDAC6ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL3427705 | 0.78 | ALDH1A1 (0.74) | HDAC1HDAC6ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL5898101 | 0.77 | HDAC1 (0.54) | HDAC1HDAC6ADAM17 | |
| SCHEMBL10143960 | 0.76 | ALDH1A1 (0.77) | HDAC1HDAC6ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL4414127 | 0.76 | ALDH1A1 (0.77) | HDAC1HDAC6ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL5897842 | 0.75 | ADAM17 (0.42) | ALDH1A1SMN1; SMN2ADAM17 | |
| SCHEMBL5897844 | 0.75 | ADAM17 (0.42) | ALDH1A1SMN1; SMN2ADAM17 | |
| SCHEMBL3427969 | 0.75 | ALDH1A1 (0.70) | HDAC1HDAC6ALDH1A1SMN1; SMN2MMP2 | |
| SCHEMBL1116630 | 0.74 | ALDH1A1 (0.78) | HDAC1HDAC6ALDH1A1SMN1; SMN2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |