Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511254 | 0.82 | GRM5 (0.54) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL3427705 | 0.81 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL7416002 | 0.80 | HDAC1 (0.54) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL10143960 | 0.80 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL4414127 | 0.80 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL27783361 | 0.79 | GRM5 (0.52) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL3427969 | 0.78 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL1116630 | 0.77 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 | |
| SCHEMBL28111220 | 0.75 | P2RX7 (0.49) | ALDH1A1GRM5TSHR | |
| SCHEMBL27903414 | 0.75 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2GRM5HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101787016-B | Pyridine carboxamides as 11-beta-hsd1 inhibitors | ASTRAZENECA AB | 2013-08-28 | — | — | CN | disclosed |
| CN-101787016-A | Pyridine carboxamides as the 11-beta-HSD 1 inhibitors | ASTRAZENECA AB | 2010-07-28 | — | — | CN | disclosed |
| CN-101573336-A | Pyridine carboxamides as 11-beta-HSD 1 inhibitors | ASTRAZENECA AB (SE) | 2009-11-04 | — | — | CN | disclosed |