Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510532 | 0.88 | LMNA (0.41) | LMNAADORA3ROCK2GSK3BPTGS2 | |
| SCHEMBL7510407 | 0.87 | ADORA3 (0.51) | ADORA3ADORA2AADORA1CYP1A2CYP2C9 | |
| SCHEMBL7509410 | 0.86 | TYR (0.44) | ADORA3ROCK2KDRGSK3BAURKB | |
| SCHEMBL7516038 | 0.80 | LMNA (0.43) | LMNAADORA3ROCK2PIM1GSK3B | |
| SCHEMBL7509548 | 0.76 | KMT2A (0.44) | LMNAALDH1A1CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL7515739 | 0.75 | MKNK1 (0.43) | LMNAADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7514619 | 0.75 | AR (0.42) | ROCK2PIM1GSK3BAURKBALDH1A1 | |
| SCHEMBL7513782 | 0.72 | AR (0.45) | ADORA2AADORA1ALDH1A1NPSR1DAO | |
| SCHEMBL7479263 | 0.65 | MAPT (0.52) | ADORA3ADORA2AADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7478026 | 0.63 | ADORA3 (0.45) | ADORA3GSK3BALDH1A1DAOPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181292-A1 | PYROZOLO [3,4-D][1,2,3] TRIAZINES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000073309-A1 | PYROZOLO [3,4-D][1,2,3] TRIAZINES WITH AN ANTICONVULSIVE ACTION AND METHODS FOR PRODUCING THE SAME | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-07 | — | — | WO | claimed |
| US-6316448-B1 | Pyrazolo[3,4-d][1,2,3] troazines having anticonvulsant activity and process for their preparation | ZENTARIS GMBH (DE) | 2001-11-13 | — | — | US | disclosed |