Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521717 | 0.84 | TP53 (0.41) | TP53ALPLRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7511983 | 0.69 | KMT2A (0.46) | TP53MAPTSMN1; SMN2PKMGAA | |
| SCHEMBL7456043 | 0.67 | ATM (0.39) | RAB9AKDM4E | |
| SCHEMBL7517598 | 0.67 | TP53 (0.58) | TP53GAATHRB | |
| SCHEMBL15767180 | 0.66 | CHEK1 (0.41) | CHEK1POLBKDM4E | |
| SCHEMBL1917210 | 0.66 | MGAM (0.47) | GAATDP1 | |
| SCHEMBL7022293 | 0.65 | CHEK1 (0.37) | CHEK1KDM4E | |
| SCHEMBL13406050 | 0.65 | TP53 (1.00) | TP53SMN1; SMN2PKMTHRB | |
| SCHEMBL8973663 | 0.64 | ATP4A (0.41) | GAAPOLBKMT2ATDP1 | |
| SCHEMBL6943657 | 0.63 | CACNA1G (0.57) | TP53RAB9ACHEK1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541146-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165519-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059887-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |