Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511591 | 0.84 | TP53 (0.48) | TP53RAB9AALPLMAPTTHRB | |
| SCHEMBL7517598 | 0.69 | TP53 (0.58) | TP53THRB | |
| SCHEMBL7511983 | 0.68 | KMT2A (0.46) | TP53MAPTPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL9406926 | 0.68 | ADORA1 (0.43) | KDM4EPRMT5POLBNOS3NOS1 | |
| SCHEMBL8561715 | 0.68 | ADORA1 (0.41) | PRMT5NOS3NOS1NOS2 | |
| SCHEMBL7378689 | 0.64 | NOS2 (0.59) | PRMT5POLBNOS3NOS1NOS2 | |
| SCHEMBL7515484 | 0.62 | TP53 (0.42) | TP53MAPTKDM4EPKMSMN1; SMN2 | |
| SCHEMBL6500874 | 0.61 | NLRP3 (0.56) | TP53RAB9AMAPTTDP1NPC1 | |
| SCHEMBL9121089 | 0.60 | ALDH1A1 (0.57) | RAB9AALPLMAPTTDP1NPC1 | |
| SCHEMBL2059383 | 0.60 | POLB (0.58) | RAB9AALPLMAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541146-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165519-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059887-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIDIABETICS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |