Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281488 | 0.85 | TSHR (0.48) | GAAKDM4ELMNATSHRNPC1 | |
| SCHEMBL1736009 | 0.81 | MAPT (0.54) | GAALMNATSHRNPC1NPSR1 | |
| SCHEMBL8806924 | 0.80 | CA12 (0.59) | GAAKDM4ELMNAALOX12NPC1 | |
| SCHEMBL9872617 | 0.80 | KDM4E (0.56) | GAAKDM4ELMNAALOX12SMN1; SMN2 | |
| SCHEMBL4722310 | 0.79 | LMNA (0.55) | GAAKDM4ELMNAALOX12SMN1; SMN2 | |
| SCHEMBL18021884 | 0.77 | LMNA (0.58) | GAAKDM4ELMNAALOX12NPSR1 | |
| SCHEMBL1030263 | 0.76 | LMNA (0.74) | GAAKDM4ELMNAALOX12NPC1 | |
| SCHEMBL999403 | 0.76 | LMNA (0.55) | GAAKDM4ELMNAALOX12SMN1; SMN2 | |
| SCHEMBL18473381 | 0.75 | GAA (0.47) | GAAKDM4ELMNAALOX12TSHR | |
| SCHEMBL11537261 | 0.75 | GPR35 (0.59) | GAAKDM4ETSHRNPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731091-B1 | 2-OXOINDOLINE DERIVATIVES AS CHOLECYSTOKININ RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-5807883-A | GASTROINTESTINAL DISORDERS; PANCREATITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0731091-A1 | 2-OXOINDOLINE DERIVATIVE | TANABE SEIYAKU CO., LTD. (JP) | 1996-09-11 | — | — | EP | disclosed |