Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917980 | 0.91 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL20788479 | 0.90 | ROCK2 (0.55) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL30529024 | 0.90 | ROCK2 (0.55) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL24502972 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1GAAROCK2MAPK14 | |
| SCHEMBL205863 | 0.84 | ROCK2 (0.52) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL205164 | 0.84 | ROCK2 (0.52) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL10923685 | 0.83 | MAPK14 (0.58) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL3029409 | 0.82 | MAPT (0.55) | KDM4EALDH1A1GAAHSD17B10ATM | |
| SCHEMBL752471 | 0.82 | SRD5A2 (0.64) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL8797606 | 0.81 | ALDH1A1 (0.64) | KDM4EALDH1A1GAAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |