Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 12/20 | 0.43 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093222 | 0.81 | NSD2 (0.44) | L3MBTL1CA2NSD2MAPTSMN1; SMN2 | |
| SCHEMBL11054324 | 0.79 | KMT2A (0.43) | L3MBTL1NSD2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1523222 | 0.78 | ALDH1A1 (0.54) | MAPTSMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL620433 | 0.78 | THRB (0.51) | MAPTSMN1; SMN2MEN1LMNAHPGD | |
| SCHEMBL10854100 | 0.75 | MAPT (0.38) | L3MBTL1NSD2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL11459274 | 0.75 | L3MBTL1 (0.51) | L3MBTL1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL26144891 | 0.74 | NPSR1 (0.47) | L3MBTL1NSD2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL16001681 | 0.74 | MAPT (0.37) | L3MBTL1NSD2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1163946 | 0.74 | MAPT (0.37) | L3MBTL1NSD2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL21124780 | 0.73 | EDNRB (0.49) | NSD2MAPTSMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527801-B1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANHYDRASE INHIBITORS | ALCON LAB INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-5240923-A | Treating glaucoma | ALCON LABORATORIES, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0527801-A4 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANYDRASE INHIBITORS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0527801-A1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5153192-A | For controlling intraocular pressure | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1991015486-A1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1991-10-17 | — | — | WO | disclosed |