Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 11/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511291 | 0.70 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL18263915 | 0.69 | CRBN (0.43) | — | |
| SCHEMBL26597131 | 0.68 | HTR2C (0.43) | PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL30643257 | 0.67 | HTR2C (0.42) | PNMTADRA2A | |
| SCHEMBL24869941 | 0.66 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11731134 | 0.66 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11731123 | 0.66 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL2061424 | 0.66 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1398082 | 0.65 | CRBN (0.43) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29370265 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |