Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7516598 | 0.75 | ALDH1A1 (0.44) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL21526447 | 0.74 | DPP7 (0.41) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11731123 | 0.71 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11731134 | 0.71 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL28564313 | 0.71 | TERT (0.44) | — | |
| SCHEMBL30561533 | 0.70 | PNMT (0.43) | PNMTADRA2A | |
| SCHEMBL20704027 | 0.70 | PNMT (0.43) | PNMTADRA2A | |
| SCHEMBL7512216 | 0.70 | PNMT (0.47) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL308120 | 0.69 | ALDH1A1 (0.52) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL22944317 | 0.68 | HDAC6 (0.44) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| EP-0861250-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017344-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1997-05-15 | — | — | WO | disclosed |