Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746358 | 0.89 | LOXL2 (0.58) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL10483392 | 0.89 | LOXL2 (0.58) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL2333461 | 0.85 | LOXL2 (0.62) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL2331919 | 0.85 | LOXL2 (0.62) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL7599320 | 0.81 | LOXL2 (0.58) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL336172 | 0.80 | LOXL2 (0.67) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL2237676 | 0.80 | LOXL2 (0.56) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL7358307 | 0.80 | LOXL2 (0.56) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL4870247 | 0.80 | LOXL2 (0.56) | LOXL2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL453732 | 0.80 | LOXL2 (0.56) | LOXL2CYP1A2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326331-B1 | Substituted quinolines and cinnolines | DOW AGROSCIENCES LLC (US) | 2002-04-17 | — | — | EP | disclosed |
| CN-1034204-C | Substituted quinolines and cinnolines | LILLY CO ELI (US) | 1997-03-12 | — | — | CN | disclosed |
| CN-1034717-A | The quinoline and the cinnolines that replace | LILLY CO ELI (US) | 1989-08-16 | — | — | CN | disclosed |