SCHEMBL7358307

SCHEMBL7358307

OCCCc1ccnc2ccccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.56
CYP1A2 P05177 1/20 0.46
NCF1 P14598 1/20 0.46
HTR1A P08908 2/20 0.45
ADRA1D P25100 2/20 0.45
ADRA1A P35348 2/20 0.45
ADRA1B P35368 2/20 0.45
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
HIF1A Q16665 1/20 0.43
KDM4E B2RXH2 4/20 0.42
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
ALDH1A1 P00352 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
POLB P06746 2/20 0.41
RAD52 P43351 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176955 0.89 LOXL2 (0.60) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL6880778 0.87 CYP19A1 (0.51) LOXL2CYP3A4KDM4ELMNASMN1; SMN2
SCHEMBL2331919 0.86 LOXL2 (0.62) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL2333461 0.86 LOXL2 (0.62) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL7599320 0.83 LOXL2 (0.58) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL334360 0.82 LOXL2 (0.67) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL31599195 0.82 LOXL2 (0.67) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL336172 0.81 LOXL2 (0.67) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL453732 0.81 LOXL2 (0.56) LOXL2CYP1A2NCF1HTR1AADRA1D
SCHEMBL4870247 0.81 LOXL2 (0.56) LOXL2CYP1A2NCF1HTR1AADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5939268-A DIELS-ALDER REACTION PRODUCT OF A DIENE AND A DIENOPHILE; CHEMICAL INTERMEDIATES FOR DRUGS, SOLID PHASE SYNTHESIS THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
EP-0773953-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS INSTITUTE (US) 1997-05-21 EP claimed
WO-1996003424-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS RESEARCH INSTITUTE (US) 1996-02-08 WO claimed
CN-108276382-A Cell cycle protein dependent kinase inhibitor and its application 南京圣和药业股份有限公司 2018-07-13 CN disclosed
CN-104168958-B Diaryl sulfonamides useful for the treatment of inflammation and cancer 坎塞拉有限公司 2017-12-01 CN disclosed
US-5817822-A ANTITUOR, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS NOVARTIS CORPORATION (US) 1998-10-06 US disclosed