Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510839 | 0.86 | KIT (0.60) | KITEGFRABCG2HTTKDM4E | |
| SCHEMBL6183340 | 0.82 | EGFR (0.61) | KITEGFRHTTKDM4ELMNA | |
| SCHEMBL16585401 | 0.81 | MAPK1 (0.65) | EGFRHTTKDM4ELMNAHPGD | |
| SCHEMBL6273407 | 0.81 | EGFR (0.57) | EGFRABCG2ERBB2HTTKDM4E | |
| SCHEMBL7512207 | 0.79 | MAPK1 (0.62) | EGFRABCG2HTTKDM4ELMNA | |
| SCHEMBL7515776 | 0.79 | EGFR (0.58) | KITEGFRABCG2ERBB2HTT | |
| SCHEMBL25511931 | 0.77 | EGFR (0.63) | KITEGFRABCG2ERBB2LMNA | |
| SCHEMBL16134156 | 0.77 | KIT (1.00) | KIT | |
| SCHEMBL19792401 | 0.76 | KDM4E (0.62) | KITEGFRHTTKDM4ELMNA | |
| SCHEMBL7516352 | 0.75 | MAPK1 (0.51) | EGFRERBB2HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6103728-A | MODULATING TYROSINE SIGNAL TRANSDUCTION TO PREVENT AND TREAT CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES; ANTICARCINOGENIC,-TUMOR, PROLIFERATIVE AGENTS | SUGEN, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0832073-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | Sugen, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040648-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |