Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517324 | 0.86 | KIT (0.60) | EGFRABCG2CSF1RBRAFKDR | |
| SCHEMBL6183340 | 0.82 | EGFR (0.61) | EGFRCSF1RKDRKITHTT | |
| SCHEMBL6273407 | 0.81 | EGFR (0.57) | EGFRABCG2CSF1RKDRMAPK14 | |
| SCHEMBL16585401 | 0.81 | MAPK1 (0.65) | EGFRCSF1RMAPK14HTTKDM4E | |
| SCHEMBL8708372 | 0.81 | EGFR (0.67) | EGFRABCG2CSF1RBRAFKDR | |
| Hydrochloric Acid SCHEMBL8503039 | 0.80 | EGFR (0.66) | EGFRABCG2CSF1RBRAFKDR | |
| SCHEMBL7512207 | 0.79 | MAPK1 (0.62) | EGFRABCG2CSF1RHTTKDM4E | |
| SCHEMBL7512753 | 0.79 | KIT (0.62) | EGFRABCG2CSF1RKITHTT | |
| SCHEMBL19792401 | 0.76 | KDM4E (0.62) | EGFRCSF1RKDRKITHTT | |
| SCHEMBL7516352 | 0.75 | MAPK1 (0.51) | EGFRCSF1RKDRHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6103728-A | MODULATING TYROSINE SIGNAL TRANSDUCTION TO PREVENT AND TREAT CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES; ANTICARCINOGENIC,-TUMOR, PROLIFERATIVE AGENTS | SUGEN, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0832073-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | Sugen, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040648-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |