Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.58 |
| ▸ | PDE5A | O76074 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30957108 | 0.84 | ALDH1A1 (0.65) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL22947697 | 0.84 | MIF (1.00) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL655570 | 0.82 | MIF (0.78) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL4340673 | 0.80 | MIF (0.74) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL3192726 | 0.79 | MIF (0.76) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL3185498 | 0.79 | MIF (0.76) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL7509505 | 0.79 | MIF (0.76) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL7509477 | 0.78 | PDE4B (0.64) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL2709876 | 0.78 | MIF (0.74) | MIFPDE4BPDE5AALDH1A1PDE3A | |
| SCHEMBL7508100 | 0.77 | MIF (0.72) | MIFPDE4BPDE5AALDH1A1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989129-B1 | PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | KYORIN SEIYAKU KK (JP) | 2002-12-11 | — | — | EP | disclosed |
| US-6265577-B1 | PHOSPHODIESTERASE INHIBITORS, BRONCHODILATORS | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0989129-A1 | PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-03-29 | — | — | EP | disclosed |