Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7510358 | 0.98 | TBXA2R (0.48) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| SCHEMBL2484589 | 0.87 | TBXA2R (0.49) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| Hydrochloric Acid SCHEMBL7513809 | 0.86 | TBXA2R (0.46) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| SCHEMBL9509823 | 0.82 | OPRM1 (0.44) | ADRB2ADRB1ADRB3PRCPGAA | |
| SCHEMBL27510456 | 0.81 | TBXA2R (0.50) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| SCHEMBL5682401 | 0.81 | HTR2A (0.56) | ADRB2ADRB1ADRB3GAAKDM4E | |
| SCHEMBL1010135 | 0.81 | HTR2A (0.54) | ADRB2ADRB1ADRB3PRCPGAA | |
| SCHEMBL13507845 | 0.81 | GAA (0.47) | TBXA2RADRB2PRCPGAAKDM4E | |
| Hydrochloric Acid SCHEMBL7509545 | 0.80 | TBXA2R (0.49) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| SCHEMBL7512552 | 0.79 | TBXA2R (0.45) | TBXA2RADRB2ADRB1ADRB3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |