Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513639 | 0.87 | TBXA2R (0.49) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| Hydrochloric Acid SCHEMBL7510358 | 0.86 | TBXA2R (0.48) | TBXA2RADRB2ADRB1ADRB3PRCP | |
| SCHEMBL31173394 | 0.81 | PNMT (0.46) | ADRB2ADRB1ADRB3PRCPGAA | |
| SCHEMBL1010297 | 0.81 | HTR2A (0.50) | ADRB2ADRB1ADRB3PRCPGAA | |
| SCHEMBL4166735 | 0.78 | MAOA (0.54) | TBXA2RKDM4EDRD2DRD4 | |
| SCHEMBL16455043 | 0.76 | PRCP (0.68) | PRCPGAAKDM4ESLC22A1OPRM1 | |
| SCHEMBL29768301 | 0.76 | PRCP (0.68) | PRCPGAAKDM4ESLC22A1OPRM1 | |
| SCHEMBL1011090 | 0.76 | PRCP (0.68) | PRCPGAAKDM4ESLC22A1OPRM1 | |
| SCHEMBL10226238 | 0.76 | PRCP (0.68) | PRCPGAAKDM4ESLC22A1OPRM1 | |
| SCHEMBL13171804 | 0.75 | ADRB2 (0.46) | TBXA2RADRB2ADRB1ADRB3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| CN-1396833-A | Integrin expression inhibitors | EISAI CO LTD (JP) | 2003-02-12 | — | — | CN | disclosed |