Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.43 |
| ▸ | CTSL | P07711 | 10/20 | 0.35 |
| ▸ | CTSS | P25774 | 12/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 7/20 | 0.33 |
| ▸ | CTSV | O60911 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508575 | 0.94 | CTSK (0.47) | CTSKCTSLCTSSKDM4EALDH1A1 | |
| SCHEMBL7445866 | 0.94 | CTSK (0.47) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL7448783 | 0.80 | CTSK (0.47) | CTSKCTSLCTSSKDM4EALDH1A1 | |
| SCHEMBL7456169 | 0.80 | CTSK (0.47) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7445830 | 0.78 | HRH1 (0.35) | CTSKCTSLCTSSKDM4EALDH1A1 | |
| SCHEMBL7449707 | 0.73 | CTSK (0.57) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453958 | 0.72 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7450638 | 0.71 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453382 | 0.71 | TAS1R3 (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453377 | 0.71 | CTSK (0.42) | CTSKCTSLCTSSKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140897-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1140897-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039115-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |