Sugi Predict

Sugi Predict / Compounds / Glutamine

Glutamine

Glutamine

SCHEMBL7514526

CC(C)C[C@H](N)C(=O)O[C@H](C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)OC(=O)[C@@H](N)COC(=O)[C@@H](N)CCCNC(=N)N.NC(=O)CC[C@H](N)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.30

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.30
▸ MAPK8 P45983 1/20 0.30
▸ MAPK9 P45984 1/20 0.30
▸ MAPK10 P53779 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proline SCHEMBL7644821 0.95 MAPK8 (0.30) MAPK8MAPK9MAPK10
Glutamine SCHEMBL5702907 0.86 KDM1A (0.31) KEAP1MAPK8MAPK9MAPK10
Arginine SCHEMBL15941501 0.83 PRCP (0.34) —
Glutamine SCHEMBL5702894 0.81 KEAP1 (0.31) KEAP1MAPK8MAPK9MAPK10
Arginine SCHEMBL1551248 0.81 PRCP (0.35) KEAP1MAPK8MAPK9MAPK10
Arginine SCHEMBL9284467 0.81 KDM1A (0.33) KEAP1MAPK8MAPK9MAPK10
Leucine SCHEMBL5702941 0.81 MAPK8 (0.30) MAPK8MAPK9MAPK10
Arginine SCHEMBL4223569 0.80 PRCP (0.33) KEAP1MAPK8MAPK9MAPK10
Arginine SCHEMBL4264472 0.80 PRCP (0.34) —
Arginine SCHEMBL1930648 0.79 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020086007-A1 Angiogenesis-inhibiting peptides and proteins and methods of use ENTREMED, INC. 2002-07-04 — — US disclosed