Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | F12 | P00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL11905093 | 0.92 | PRCP (0.38) | PRCPKMT2AMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL23248653 | 0.92 | PRCP (0.38) | PRCPKMT2AMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL14841994 | 0.92 | PRCP (0.38) | PRCPKMT2AMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL8587127 | 0.92 | ALOX15 (0.33) | PRCPALOX15BLMPMP22KMT2A | |
| Arginine SCHEMBL28831176 | 0.90 | PRCP (0.32) | PRCP | |
| Glutamine SCHEMBL5702907 | 0.90 | KDM1A (0.31) | KEAP1MAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL25168271 | 0.90 | PRCP (0.36) | PRCPKMT2AMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL11905292 | 0.90 | PRCP (0.35) | PRCP | |
| Arginine SCHEMBL2501111 | 0.89 | PRCP (0.36) | PRCPKMT2AMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL17982370 | 0.89 | PRCP (0.36) | PRCPKMT2AMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090075932-A1 | METHOD OF SELECTIVELY INHIBITING PKCiota | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-03-19 | — | — | US | claimed |
| WO-2009036414-A1 | METHOD OF SELECTIVELY INHIBITING PKCIOTA | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-03-19 | — | — | WO | claimed |
| US-8461192-B2 | Method of selectively inhibiting PKCiota | THE UNIVERSITY OF SOUTH FLORIDA (US) | 2013-06-11 | — | — | US | disclosed |
| US-20090075932-A1 | METHOD OF SELECTIVELY INHIBITING PKCiota | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-03-19 | — | — | US | disclosed |
| WO-2009036414-A1 | METHOD OF SELECTIVELY INHIBITING PKCIOTA | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-03-19 | — | — | WO | disclosed |