SCHEMBL7514564

SCHEMBL7514564

COC(=O)c1c2c(cc3c1OC(C)(C)O3)OC(C)(C)O2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.45
ALDH1A1 P00352 5/20 0.41
CYP3A4 P08684 2/20 0.40
ACHE P22303 1/20 0.40
HPGD P15428 3/20 0.38
CA12 O43570 2/20 0.37
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CA7 P43166 2/20 0.37
CA9 Q16790 2/20 0.37
CA14 Q9ULX7 2/20 0.37
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 3/20 0.33
HTT P42858 1/20 0.33
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8930643 0.86 TSHR (0.36) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL9273756 0.86 TSHR (0.36) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL7514575 0.81 CYP3A4 (0.45) TSHRALDH1A1CYP3A4HPGDCA12
SCHEMBL8930700 0.81 TSHR (0.52) TSHRALDH1A1HPGDNPC1CYP1A2
SCHEMBL10521417 0.80 ALDH1A1 (0.43) ALDH1A1CYP3A4ACHEHPGDCA12
SCHEMBL7519849 0.79 TSHR (0.50) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL8930693 0.79 ALDH1A1 (0.38) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL3566260 0.77 LMNA (0.51) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL10521834 0.77 MAPT (0.38) TSHRALDH1A1CYP3A4ACHEHPGD
SCHEMBL8930727 0.75 ALDH1A1 (0.35) ALDH1A1CYP3A4ACHEHPGDCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871896-B1 A METHOD OF DETERMINING OXYGEN CONCENTRATION IN A SAMPLE NYCOMED IMAGING AS (NO) 2002-01-30 EP disclosed
US-6256527-B1 Method for determining oxygen concentration NYCOMED IMAGING AS (NO) 2001-07-03 US disclosed
EP-0832054-B1 HETEROCYCLIC METHYL FREE RADICALS AS IMAGE ENHANCING AGENTS NYCOMED IMAGING AS (NO) 2000-12-27 EP disclosed
US-6063360-A USEFUL AS CONTRAST AGENT FOR OVERHAUSER MAGNETIC RESONACE IMAGING NYCOMED IMAGING A/S (NO) 2000-05-16 US disclosed
EP-0871896-A1 A METHOD OF DETERMINING OXYGEN CONCENTRATION IN A SAMPLE NYCOMED IMAGING AS (NO) 1998-10-21 EP disclosed
EP-0832054-A1 HETEROCYCLIC METHYL FREE RADICALS AS IMAGE ENHANCING AGENTS NYCOMED IMAGING AS (NO) 1998-04-01 EP disclosed
WO-1997009633-A1 A METHOD OF DETERMINING OXYGEN CONCENTRATION IN A SAMPLE NYCOMED IMAGING A/S (NO) 1997-03-13 WO disclosed
WO-1996039367-A1 HETEROCYCLIC METHYL FREE RADICALS AS IMAGE ENHANCING AGENTS NYCOMED IMAGING A/S (NO) 1996-12-12 WO disclosed
US-5530140-A Free radicals NYCOMED IMAGING AS (NO) 1996-06-25 US disclosed