Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503090 | 0.95 | GSK3B (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7506991 | 0.93 | ALOX15 (0.44) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7509254 | 0.93 | ALDH1A1 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7514736 | 0.90 | ALOX15 (0.48) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7502054 | 0.89 | KDM4E (0.46) | ALOX15ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7507638 | 0.89 | ALOX15 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7501257 | 0.89 | ALOX15 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7508929 | 0.89 | ALOX15 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7506242 | 0.89 | ALOX15 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD | |
| SCHEMBL7506263 | 0.89 | ALOX15 (0.49) | GSK3BALOX15ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |