Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | HTR1B | P28222 | 7/20 | 0.37 |
| ▸ | HTR1D | P28221 | 7/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519588 | 0.95 | MTNR1A (0.51) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Maleic Acid SCHEMBL9238804 | 0.91 | MTNR1A (0.46) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Fumaric Acid SCHEMBL9238809 | 0.91 | MTNR1A (0.46) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL8891420 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL9641417 | 0.83 | MTNR1A (0.41) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL7516393 | 0.82 | HTR1A (0.49) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL7513603 | 0.82 | MTNR1A (0.40) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Bromide SCHEMBL7513869 | 0.80 | HTR1A (0.49) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Phosphoric Acid SCHEMBL7509101 | 0.79 | HTR1A (0.46) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Oxalic Acid SCHEMBL7513247 | 0.78 | HTR1A (0.47) | MTNR1AMTNR1BHTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |