Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 6/20 | 0.42 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.34 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.34 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 4/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | HTR1E | P28566 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9238804 | 1.00 | MTNR1A (0.46) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL7519588 | 0.93 | MTNR1A (0.51) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Formic Acid SCHEMBL7514970 | 0.91 | MTNR1A (0.47) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL8891420 | 0.85 | MTNR1A (0.52) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Fumaric Acid SCHEMBL7514859 | 0.84 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Maleic Acid SCHEMBL7514854 | 0.84 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| Fumaric Acid SCHEMBL7515760 | 0.84 | HTR1A (0.42) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL9641417 | 0.81 | MTNR1A (0.41) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL7516393 | 0.81 | HTR1A (0.49) | MTNR1AMTNR1BHTR1AHTR1BHTR1D | |
| SCHEMBL7513603 | 0.80 | MTNR1A (0.40) | MTNR1AMTNR1BHTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |