SCHEMBL7515285

SCHEMBL7515285

CCOC(=O)Oc1cc2ccccc2n1-c1ccccc1[N+](=O)[O-]

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 3/20 0.42
NOD1 Q9Y239 3/20 0.42
ALDH1A1 P00352 7/20 0.42
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
SLC5A1 P13866 1/20 0.39
SLC5A2 P31639 1/20 0.39
HTT P42858 1/20 0.38
KDM4E B2RXH2 1/20 0.38
RAB9A P51151 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
CACNA1F O60840 1/20 0.37
CACNA1D Q01668 1/20 0.37
CACNA1S Q13698 1/20 0.37
CACNA1C Q13936 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
MAPT P10636 5/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7517971 0.82 NOD2 (0.52) NOD2NOD1ALDH1A1SMN1; SMN2HTT
SCHEMBL6303208 0.82 NOD2 (0.56) NOD2NOD1ALDH1A1GAASMN1; SMN2
SCHEMBL6175583 0.75 AR (0.47) NOD2NOD1ALDH1A1GAASMN1; SMN2
SCHEMBL9266851 0.74 MCL1 (0.46) NOD2NOD1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL11980494 0.73 NOD2 (0.48) NOD2NOD1ALDH1A1GAASMN1; SMN2
SCHEMBL19543206 0.71 RAB9A (0.58) ALDH1A1GAASMN1; SMN2HTTKDM4E
SCHEMBL8568270 0.71 ALDH1A1 (0.43) ALDH1A1GAAHTTCYP1A2CYP3A4
SCHEMBL9239322 0.70 ALDH1A1 (0.55) NOD2NOD1ALDH1A1SMN1; SMN2HTT
SCHEMBL6608082 0.68 MAPT (0.51) ALDH1A1GAASMN1; SMN2RAB9AMAPT
SCHEMBL6172815 0.67 KMT2A (0.49) ALDH1A1SMN1; SMN2CYP1A2CACNA1FCACNA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165512-A2 METHOD FOR ARYLATING AZA-HETEROCYCLES WITH ACTIVATED AROMATIC COMPOUNDS IN THE PRESENCE OF CESIUM CARBONATE GÖDECKE GMBH (DE) 2002-01-02 EP disclosed
WO-2000059883-A2 METHOD FOR PRODUCING N-ARYL-AZA-HETEROCYCLES IN THE PRESENCE OF CESIUM CARBONATE Gödecke GmbH (DE) 2000-10-12 WO disclosed