Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515617 | 0.88 | TRPV1 (0.40) | TRPV1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL7516429 | 0.88 | MAPK13 (0.48) | TRPV1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL7035666 | 0.85 | MAPK14 (0.47) | TRPV1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL7037214 | 0.84 | ADRA2A (0.43) | TRPV1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL7037911 | 0.84 | MAPK14 (0.47) | ADRA2AADRA2BADRA2CADRA1AMAPK14 | |
| SCHEMBL7032158 | 0.82 | MAPT (0.41) | ADRA2AADRA2BADRA2CADRA1AMAPK14 | |
| SCHEMBL7037861 | 0.81 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1AMAPK14 | |
| SCHEMBL7036632 | 0.75 | MAPK14 (0.47) | TRPV1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7081224 | 0.74 | ADRA2A (0.42) | TRPV1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL7081225 | 0.74 | ADRA2A (0.42) | TRPV1ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-07 | — | — | US | claimed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | IL1B, IL1A, NFKBIA | TRPV1 3746/4885ADRA2A 964/4885ADRA2B 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.