Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.68 |
| ▸ | MMP3 | P08254 | 19/20 | 0.68 |
| ▸ | MMP9 | P14780 | 14/20 | 0.68 |
| ▸ | MMP7 | P09237 | 13/20 | 0.68 |
| ▸ | MMP12 | P39900 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 11/20 | 0.55 |
| ▸ | MMP8 | P22894 | 6/20 | 0.55 |
| ▸ | MMP13 | P45452 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132462 | 0.88 | MMP1 (0.71) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7080356 | 0.87 | MMP1 (0.73) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7080532 | 0.81 | MMP3 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7078092 | 0.80 | MMP1 (0.62) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7082082 | 0.78 | MMP1 (0.60) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7509736 | 0.76 | MMP1 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL10118093 | 0.75 | MMP3 (0.85) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7077683 | 0.74 | MMP1 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7081687 | 0.74 | MMP1 (0.71) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7081790 | 0.73 | MMP3 (1.00) | MMP1MMP3MMP9MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927168-B1 | 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6469000-B1 | TREATING ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, SKIN DISORDERS, OCULAR DISORDERS, INFLAMMATION AND GUM DISEASE | THE PROCTER & GAMBLE CO. | 2002-10-22 | — | — | US | disclosed |
| US-6465474-B1 | TREATMENT OF SUCH AS OSTEOARTHITIS, RHEUMATOID ARTHRITIS, PREVENTION OR ARREST OF TUMOR GROWTH AND METASTASIS, CORNEAL ULCERATION, LACK OF CORNEAL HEALING, MACULAR DEGENERATION, PERIODONTAL DISEASE, GINGIVITIS | THE PROCTER & GAMBLE COMPANY | 2002-10-15 | — | — | US | disclosed |
| US-6150370-A | 1,3-DINITROCYCLIC COMPOUND TREATS NUMEROUS DISEASES CAUSED BY UNDESIRED METALLOPROTEASE ACTIVITY, SUCH AS TUMOR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SKIN INFLAMMATION, ULCERATIONS, AND PERIODONTITIS | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-21 | — | — | US | disclosed |