Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.71 |
| ▸ | MMP3 | P08254 | 18/20 | 0.71 |
| ▸ | MMP9 | P14780 | 14/20 | 0.68 |
| ▸ | MMP7 | P09237 | 14/20 | 0.68 |
| ▸ | MMP12 | P39900 | 1/20 | 0.65 |
| ▸ | MMP2 | P08253 | 6/20 | 0.64 |
| ▸ | MMP8 | P22894 | 5/20 | 0.64 |
| ▸ | MMP13 | P45452 | 5/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509736 | 0.83 | MMP1 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL5639174 | 0.82 | MMP1 (0.69) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL7080356 | 0.81 | MMP1 (0.73) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7077683 | 0.81 | MMP1 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7081790 | 0.80 | MMP3 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL7080532 | 0.79 | MMP3 (1.00) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL11933919 | 0.79 | MMP1 (0.90) | MMP1MMP3MMP9MMP7MMP12 | |
| SCHEMBL5637314 | 0.78 | MMP1 (0.64) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL5639216 | 0.77 | MMP7 (0.65) | MMP1MMP3MMP9MMP7MMP2 | |
| Hydrochloric Acid SCHEMBL5638870 | 0.76 | MMP1 (0.60) | MMP1MMP3MMP9MMP7MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130271-A1 | 1,3-Diheterocyclic metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY | 2003-07-10 | — | — | US | disclosed |
| EP-0927168-B1 | 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6150370-A | 1,3-DINITROCYCLIC COMPOUND TREATS NUMEROUS DISEASES CAUSED BY UNDESIRED METALLOPROTEASE ACTIVITY, SUCH AS TUMOR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SKIN INFLAMMATION, ULCERATIONS, AND PERIODONTITIS | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0927168-A1 | 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998008822-A1 | 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130271-A1 | 1,3-Diheterocyclic metalloprotease inhibitors | ADAM17, TIMP3, MMP3 | MMP1 7/4885MMP3 3/4885MMP9 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.