Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 12/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518627 | 0.91 | SMN1; SMN2 (0.40) | MAPK13MAPK12MAPK11MAPK14CCR5 | |
| SCHEMBL7513571 | 0.90 | MAPK13 (0.37) | MAPK13MAPK12MAPK11MAPK14CCR5 | |
| SCHEMBL7510773 | 0.83 | MAPK14 (0.68) | MAPK13MAPK12MAPK11MAPK14POLB | |
| SCHEMBL7514380 | 0.80 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7033611 | 0.79 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7037902 | 0.76 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7030739 | 0.75 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL7596971 | 0.74 | CMA1 (0.40) | MAPK13MAPK12MAPK11MAPK14CCR5 | |
| SCHEMBL7518332 | 0.74 | MAPK14 (0.55) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7032174 | 0.74 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |