Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 10/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515830 | 0.87 | GAA (0.36) | PTGER1GAA | |
| SCHEMBL7509430 | 0.87 | PTGER1 (0.36) | PTGER1GAACCR2 | |
| SCHEMBL7513617 | 0.86 | GAA (0.38) | PTGER1GAAPPARG | |
| SCHEMBL7516138 | 0.85 | PTGER1 (0.36) | PTGER1GAACCR2 | |
| SCHEMBL7511101 | 0.84 | PTGER1 (0.36) | PTGER1GAACCR2 | |
| SCHEMBL7506976 | 0.82 | PTGER1 (0.37) | PTGER1GAA | |
| SCHEMBL7209116 | 0.81 | GAA (0.38) | PTGER1GAA | |
| SCHEMBL7982398 | 0.81 | UTS2R (0.35) | PTGER1GAA | |
| SCHEMBL7511096 | 0.80 | GAA (0.35) | PTGER1GAACCR2 | |
| SCHEMBL7508378 | 0.80 | PTGER1 (0.37) | PTGER1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051173-A4 | DERIVATIVES OF 1,3,4-OXADIAZOLONE | BRISTOL MYERS SQUIBB CO (US) | 2002-07-31 | — | — | EP | claimed |
| EP-1051173-A1 | DERIVATIVES OF 1,3,4-OXADIAZOLONE | Bristol-Myers Squibb Company (US) | 2000-11-15 | — | — | EP | claimed |
| US-6034113-A | ANTIISCHEMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-07 | — | — | US | claimed |
| WO-1999038510-A1 | DERIVATIVES OF 1,3,4-OXADIAZOLONE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-08-05 | — | — | WO | claimed |