Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516302 | 1.00 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL6752996 | 0.84 | LMNA (0.68) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL8399917 | 0.83 | SMN1; SMN2 (0.61) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL27597146 | 0.83 | DHODH (0.53) | ALDH1A1MEN1KMT2APKMDHODH | |
| SCHEMBL5113527 | 0.80 | KMT2A (0.70) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL5113536 | 0.80 | KMT2A (0.70) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL3483129 | 0.79 | KMT2A (0.56) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL4009130 | 0.79 | FFAR4 (0.46) | ALDH1A1KMT2ALMNADHODHMAPT | |
| SCHEMBL622263 | 0.78 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2APKMLMNA | |
| SCHEMBL117243 | 0.78 | HCAR3 (0.50) | ALDH1A1MEN1KMT2ADHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966473-B1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-07-24 | — | — | EP | disclosed |
| EP-0966473-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038194-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1998-09-03 | — | — | WO | disclosed |