Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 10/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515776 | 0.86 | EGFR (0.58) | KITEGFRABCG2KDRCSF1R | |
| SCHEMBL19792401 | 0.84 | KDM4E (0.62) | KITEGFRKDRCSF1RPDE10A | |
| SCHEMBL7510762 | 0.83 | EGFR (0.58) | EGFRABCG2KDRPDE10AKDM4E | |
| SCHEMBL7516992 | 0.83 | MAPK1 (0.63) | EGFRKDRCSF1RPDE10AKDM4E | |
| SCHEMBL19797771 | 0.83 | RET (0.56) | EGFRKDRPDE10AKDM4EALDH1A1 | |
| SCHEMBL6183340 | 0.82 | EGFR (0.61) | KITEGFRKDRCSF1RKDM4E | |
| SCHEMBL7512207 | 0.82 | MAPK1 (0.62) | EGFRABCG2CSF1RPDE10AKDM4E | |
| SCHEMBL7510839 | 0.80 | KIT (0.60) | KITEGFRABCG2PDE10AMAPK7 | |
| SCHEMBL18158153 | 0.79 | EGFR (0.60) | KITEGFRKDRCSF1RPDE10A | |
| SCHEMBL7516352 | 0.78 | MAPK1 (0.51) | EGFRKDRCSF1RPDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6103728-A | MODULATING TYROSINE SIGNAL TRANSDUCTION TO PREVENT AND TREAT CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES; ANTICARCINOGENIC,-TUMOR, PROLIFERATIVE AGENTS | SUGEN, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0832073-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | Sugen, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040648-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |